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KMID : 0370219840280040207
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Yakhak Hoeji
1984 Volume.28 No. 4 p.207 ~ p.215
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Effects of a Chinese Traditional Medicine, Ssang Wha Tang, on the Pharmacokinetics of Sulfobromophthalein in the Rats of Hepatic Failure Induced by Carbon Tetrachloride
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안병락/Ann BN
김신근/심창구/정연복/Kim SK/Shim CK/Chung YB
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Abstract
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Effects of Ssang Wha Tang (SWT), a blended Chinese traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride + SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic parameters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was rather larger than that in Group I, the replacement of BSP-plasma protein binding in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction (fp) in Group II than that in Group I might also explain the increases of BSP clearance and Vdss in Group II compared to Group I. Assuming no changes in hepatic plasma flow(Q) in each group, hepatic intrinsic clearance(CLhint) decreased in Group I did not recover at all in Group II. Therefore SWT seemed not to have any restoring effect of true hepatic-function to biotransform and excrete BSP, and the apparent restoring effect of SWT might be due only to the replacement of BSP-plasma protein binding. Whether fp is actually higer in Group II than in Group I, and Q is constant in each group are being examined in our laboratory. The changes of Q, which might lead to another conclusions, also should be taken into consideration to clarify the apparent hepato-restoring effect of SWT.
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KEYWORD
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